Alzheimer’s Disease Genetics Consortium (ADGC)

At a Glance
  • Status: Completed Consortium
  • Year Launched: 2009
  • Initiating Organization: University of Pennsylvania
  • Initiator Type: Academia
  • Disease focus:
    Alzheimer's Disease
  • Location: North America

Abstract

The Alzheimer’s Disease Genetics Consortium (ADGC) was founded to conduct genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD). This five-year consortium, spanning universities from both Europe and the United States, will combine the knowledge, staff, and resources of four existing consortia that conduct research on Alzheimer's disease genetics.

Mission

ADGC’s goal is to identify genetic variants associated with risk for Alzheimer’s disease (AD). The effort leverages the current knowledge that genetic factors play an important role in the development of AD. For example, it has been shown through familial aggregation studies that first degree relatives of probands with AD are more likely to have or develop AD compared to relatives of controls. Twin studies show a higher concordance of AD among monozygotic compared to dizygotic twins, with heritability estimates of 60% to 80%. This five-year consortium, spanning universities from both Europe and the United States, will combine the knowledge, staff, and resources of four existing consortia that conduct research on Alzheimer's disease genetics.

Consortium History

2009: Gerard Schellenberg, PhD, professor of pathology and laboratory medicine, received an $18.3 million, five-year grant from the National Institute on Aging to lead ADGC.

Structure & Governance

An Executive Committee oversees ADGC and makes major decisions on administrative and scientific matters by voting. Executive Committee members include key members (principal investigators [PI] and Co-PIs) of the ADGC research proposal and representatives from institutions that contribute a major portion of samples to the ADGC study.

ADGC is supported by six subcommittees, all of which report to the Executive Committee:

Financing

ADGC is funded by a grant from the National Institute on Aging (PI, Gerard D. Schellenberg; UO1AG032984), an $18.3 million, five-year research grant to conduct GWAS to identify genes associated with an increased risk of developing LOAD.

Data Sharing

To request or submit data to ADGC, please contact: data@mail.med.upenn.edu

Impact/Accomplishment

Since 2010, 25 ADGC reports/papers have been published.

Points of Contact

For queries and comments regarding ADGC, please contact:
Laura Cantwell
Department of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
422 Curie Boulevard
Philadelphia, PA 19104-6082
email: Lcant@mail.med.upenn.edu

For queries and comments on the ADGC website, please contact:
Otto Valladares
email: ottov@mail.med.upenn.edu

Sponsors & Partners

Banner Alzheimer’s Institute

Boston University

Children’s Hospital of Philadelphia

Columbia University

Duke University Medical Center

Einstein

Emory University

Florida Alzheimer’s Center           

Genentech

Indiana University

Johns Hopkins

Lou Ruvo Brain Institute               

Massachusetts General

Mayo Clinic

Mayo Clinic College of Medicine

Mayo Clinic Florida

Mount Sinai School of Medicine

National Alzheimer’s Coordinating Center

National Institute on Aging                                    

National Institutes of Health

New York University

Northwestern University Medical School

Oregon Health Sciences University

Rush University Medical Center

Stanford University

The Hospital for Sick Children

University of Alabama

University of Arkansas for Medical Sciences

University of California, Davis

University of California, Irvine

University of California, Los Angeles

University of California, San Diego

University of California, San Francisco

University of Chicago

University of Gothenburg 

University of Kentucky

University of Miami

University of Michigan

University of North Texas

University of Pennsylvania

University of  Pittsburgh

University of San Diego

University of Southern California

University of Texas Southwestern

University of Toronto

University of Virginia

University of Washington

USC, Los Angeles

Vanderbilt University

Wake Forest University

Washington University


Last Updated: 04/06/2016

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