AgedBrainSYSBIO

At a Glance
  • Status: Active Consortium
  • Year Launched: 2013
  • Initiating Organization: European Comission Seventh Framework Programme (FP7)
  • Initiator Type: Government
  • Disease focus:
    Alzheimer's Disease
  • Location: Europe

Abstract

AgedBrainSYSBIO focuses on identifying the foundational pathways responsible for the aging of the brain, with a focus on late-onset Alzheimer’s disease (LOAD). By combining integrative systems biology and comparative genomics, the consortium aims to identify the interactions through which the aging phenotype develops in normal and in disease conditions and to model novel pathways and their evolutionary properties to design experiments that identify druggable targets.

Mission

AgedBrainSYSBIO’s mission is to address the basis of brain aging by studying the pathways involved in this process and by identifying the interactions through which the aging phenotype develops in normal and in disease conditions. The consortium aims to identify and validate new molecular targets and biomarkers associated with LOAD. Because early steps of neurodegenerative disorders are expected to impact synapse function, the project will focus in particular on pre- or post- synaptic protein networks. 

The project consists of 13 research teams from academia and industry. The scientists will share their findings about LOAD genome-wide association studies (GWAS) gene discovery, comparative functional genomics in mouse and drosophila models, in mouse transgenic approaches, human induced pluripotent stem cells and their differentiation in vitro, and modeling pathways with an emphasis on comparative and evolutionary aspects.

The concept is to identify subsets of pathways with two unique druggable hallmarks: (a) the validation of interactions occurring locally in subregions of neurons and (b) a human and/or primate accelerated evolutionary signature. 

The project will achieve its objectives through seven approaches:

Consortium History

March 19, 2013: AgedBrainSYSBIO was officially launched in Paris, France.
Other news and events 

Structure & Governance

AgedBrainSYSBIO is coordinated by the French National Institute for health and medical research and brings together scientists with expertise in systems biology of the synapse and four small- to medium-size enterprises (SMEs) with a leading role in the project. In addition, an independent Advisory Board provides guidance on scientific, ethical, and regulatory aspects related to the project’s research activities.

AgedBrainSYSBIO is supported by two independent external advisors. The scientific advisor has a consultative function and advises the project in terms of work program, scientific quality, and strategy. Because of the nature of the project, an independent ethics advisor monitors all ethical and regulatory concerns raised in the project.

Financing

With a total cost of €8.2 million,  the European Commission funds €6.0 million under the Health Cooperation Programme of the Seventh Framework Programme (FP7); Grant Agreement No 305299.

Intellectual Property

Inserm Transfert, a private subsidiary of Inserm, is involved in the activities of intellectual property management. Because the project is funded by the European Commission’s Seventh Framework Programme, AgedBrainSYSBIO participants adhere to the guidelines published here

Data Sharing

The scientists will share findings on LOAD GWAS gene discovery, comparative functional genomics in mouse and drosophila models, in mouse transgenic approaches, human induced pluripotent stem cells and their differentiation in vitro, and modeling pathways with an emphasis on comparative and evolutionary aspects. Importantly, the four European SMEs involved will bring their complementary expertise and will ensure translation of project results to clinical application. In addition, an independent Advisory Board provides guidance on scientific, ethical, and regulatory aspects related to the project’s research activities.

Points of Contact

Michel Simonneau (Coordinator)
INSERM U894 - Centre for Psychiatry and Neuroscience
2 ter Rue d’Alésia
75014 Paris, France
email: michel.Simonneau@inserm.fr

Christiane Dascher-Nadel (Project Manager)
Inserm Transfert SA
18 avenue Mozart - BP172
13276 Marseille Cedex 09
France
email: christiane.dascher-nadel@inserm-transfert.fr

Sponsors & Partners

Babraham Institute

EMBL-EBI

Gene Bridges GmbH

Heinrich Heine Universität Düsseldorf (UDUS)

HYBRIGENICS

Inserm

Inserm Transfert SA

Institut Clinique de la Souris (ICS) (Mouse Clinical Institute, MCI)

Institut Pasteur de Lille

Quretec ltd

reMYND NV

Swiss Institute of Bioinformatics (SIB)

Tel Aviv University

VIB


Last Updated: 04/06/2016

The Consortia-pedia Catalogue is a living resource, and we are always adding new consortia. Provide information here about your collaboration to apply to be included in the Catalogue.

All the information contained in the Consortia-pedia was collected from publically available sources. Decisions to include or exclude a particular listing from Consortia-pedia were also made on the basis of publically available information and the criteria outlined in the FAQs. This site is intended to be an objective resource for the community, and inclusion does not constitute or imply endorsement, recommendation, or approval by FasterCures or the Milken Institute.