A GABRIEL Consortium Large-Scale Genome-Wide Association Study of Asthma

At a Glance
  • Status: Completed Consortium
  • Year Launched: 2006
  • Initiating Organization: Wellcome Trust
  • Initiator Type: Third-party organization
  • Disease focus:
    Asthma
  • Location: Europe

Abstract

The European GABRIEL Consortium in conjunction with partners from many other countries undertook the largest study to date in the genetics of asthma. This was a  genome-wide association study by genotyping 10,365 persons with physician-diagnosed asthma, as well as 16,110 unaffected persons obtained from 23 individual studies. Random-effects pooled analysis was applied to test for association in all subjects and in subgroups of childhood-onset (present below the age of 16 years), adult-onset, severe, and occupational asthma.

Mission

European cases and population-matched controls were obtained from clinics and cohort and cross-sectional population surveys, including some family-based studies, cases, and controls from the first-generation, genome-wide association study, and cases and controls of European descent from Canadian, Australian, and U.S. surveys. Asthma was considered present if diagnosed by a physician. Childhood-onset asthma was defined as being present below the age of 16 years and adult-onset asthma to have started at 16 years or older. Some surveys contributed samples to both age-of-onset groups. Other subgroups consisted of cases of unknown age of onset, cases with occupational asthma, or cases of severe asthma. All participants or their parents provided signed informed consent to participate in the study, according to the rules of local ethics committee. After quality control and filtering, genotype on 582,892 single nucleotide polymorphism (SNPs) on 10,365 cases and 16,110 controls from 23 different studies were retained.

Financing

This work was supported by the European Commission as part of GABRIEL (A multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community) contract number 018996 under the Integrated Program LSH-2004-1.2.5-1. The study was also funded by the Wellcome Trust under WT084703MA: “A second-generation genome-wide association study for asthma,” Asthma UK (the Asthma UK genetics of severe asthma study (AUGOSA)) and the Ministère de l’Enseignement supérieur et de la Recherche (CEPH and CNG).

Data Sharing

The results file, available on the consortia website, contains the statistics divided by age-category and study in addition to pooled results for all the markers retained in the analysis after quality control.

Impact/Accomplishment

The consortium’s activities resulted in an article published in the New England Journal of Medicine on Sept. 23, 2010. “A Large-Scale, Consortium-Based Genomewide Association Study of Asthma” is linked on the consortium’s website.

Sponsors & Partners

Aalborg Hospital

Abt. Fuer Kinderheilkunde Foschungsinstitut zur Praevention von Allergien und Atemwegserkrankungen im Kindesalter

Academic Unit of Respiratory Medicine

Aristotle University of Thessaloniki

AstraZeneca

Astrid Lindgren Children’s Hospital

AUGOSA Study Investigator

Avon Longitudinal Study of Parents and Children (ALSPAC) Investigator

BAMSE Study Investigator

Beatrix Children’s Hospital

Birmingham Heartlands Hospital and University of Birmingham

British 1958 Birth Cohort (B58C) Investigator

Canadian Childhood Cohorts: Canadian Asthma Primary Prevention Study (CAPPS) & Study of Asthma Genes and Environment (SAGE) Investigator

Centre for Research in Environmental Epidemiology (CREAL)

Centre Hospitalier Universitaire

Charité Universitätsmedizin Berlin

CIBER Epidemiologia y Salud Pública (CIBERESP)

Clinic for Paediatric Pneumology and Neonatology, Hannover Medical School

Epidemiological study on the Genetics and Environment of Asthma (EGEA) Investigator

Erasmus University Medical Centre

European Community Respiratory Health Survey (ECRHS) Investigator

Fondation Jean Dausset-CEPH

GABRIEL Advanced Surveys (GABRIEL AS) Investigator

Galdakao Hospital

Genetics of Asthma International Network (GAIN) Investigator

German Research Centre for Environmental Health (GmbH)

GlaxoSmithKline R & D

Haukeland University Hospital

Helmholtz Zentrum

Helmholtz Zentrum Munich Institute of Epidemiology

Helsinki University Central Hospital

Hospital General de Asturias

Hospital General Universitario de Albacete

Hospital Juan Ramón Jiménez

Imperial College

Industrial Cohorts Research Group Investigator

Innsbruck Medical University

Inserm

Institut de Génomique

Institute of Social and Preventive Medicine

KARELIA Allergy Study (KARELIA) Investigator

Karolinska Institutet

KSMU Study Investigator

Kursk State Medical University

Max-Delbrück-Centrum (MDC) for Molecular Medicine

Member of the GABRIEL Consortium

Municipal Institute of Medical Research (IMIM-Hospital del Mar)

National Heart and Lung Institute, Imperial College, London

National Institute for Health and Welfare, Helinski

National Institute for Public Health and the Environment

National School of Public Health, Athens

Nottingham Respiratory Biomedical Research Unit

Ontario Institute for Cancer Research

Oslo University Hospital and Faculty of Medicine

PathWest Laboratory Medicine

PIAMA Study Investigator

Queen’s University of Belfast

Radboud University Nijmegen Medical Centre

Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences

Royal Brompton Hospital

Sachs Children’s Hospital

Saguenay-Lac-Saint-Jean (SLSJ) Familial Collection Investigator

Sanquin Research,  Department of Immunopathology, Amsterdam

SEVERE ASTHMA COHORTS Investigator

Siberian State Medical University

Sir Charles Gairdner Hospital

St George’s University of London

Swiss study on Air Pollution and Lung Disease In Adults (SAPALDIA) Investigator

Swiss Tropical and Public Health Institute

Tartu University Hospital

The Busselton Health Study (BUSSELTON) Investigator

The German Multicenter Allergy Study (MAS) Investigator

The University of Manchester

TOMSK Study Investigator

UFA Scientific Centre

UFA Study Investigator

Ulm University

Umeå University

Universitat Pompeu Fabra (UPF)

Université due Québec à Chicoutimi

Université Joseph Fourier

Université Paris Diderot

Université Paris-Sud

University Children’s Hospital

University Hospitals of Geneva

University Medical Center

University Medical Center Groningen

University of Aarhus

University of Aberdeen

University of Alberta and School of Public Health

University of Basel

University of Bergen

University of Bristol

University of British Columbia

University of Glasgow

University of Leicester

University of Manitoba

University of Minnesota

University of Montreal

University of Munich

University of Southampton School of Medicine

University of Uppsala

University of Utrecht

University of Western Australia

Wellcome Trust Centre for Human Genetics

West Australian Sleep Disorders Research Institute

Wroclaw Medical University


Last Updated: 04/14/2016

The Consortia-pedia Catalogue is a living resource, and we are always adding new consortia. Provide information here about your collaboration to apply to be included in the Catalogue.

All the information contained in the Consortia-pedia was collected from publically available sources. Decisions to include or exclude a particular listing from Consortia-pedia were also made on the basis of publically available information and the criteria outlined in the FAQs. This site is intended to be an objective resource for the community, and inclusion does not constitute or imply endorsement, recommendation, or approval by FasterCures or the Milken Institute.