International Mouse Phenotyping Consortium (IMPC)

At a Glance
  • Status: Active Consortium
  • Year Launched: 2011
  • Initiating Organization: MRC Harwell
  • Initiator Type: Third-party organization
  • No disease focus
  • Location: International

Abstract

The goal of the International Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains. IMPC is generating a knockout mouse strain for every protein coding gene by using the embryonic stem (ES) cell resource generated by the International Knockout Mouse Consortium (IKMC). The production of mouse strains from these ES cells are tracked within the “international Micro-injection tracking system” (iMits) and are made available to the research community via public repositories.

Mission

IMPC’s goals are as follows:

  • Maintain and expand a worldwide consortium of institutions with capacity and expertise to produce germline transmission of targeted knockout mutations in embryonic stem cells for 20,000 known and predicted mouse genes

  • Test each mutant mouse line through a broad-based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease

  • Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems

  • Maintain and expand collaborative networks with specialist phenotyping consortia or laboratories, providing standardized secondary-level phenotyping that enriches the primary dataset, as well as end-user, project-specific, tertiary-level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis-driven research

  • Provide a centralized data center and portal for free, unrestricted access to primary and secondary data by the scientific community, promoting sharing of data, genotype-phenotype annotation, standard operating protocols, and the development of open-source data analysis tools

Members of the IMPC may include research centers, funding organizations, and corporations.

Structure & Governance

The IMPC Steering Committee provides the governance for the overall consortium. Participants are tasked with making key strategic decisions, including selection of participating organizations, approving and coordinating key operational decisions such as phenotyping platforms and pipeline used, quality assurance and operating standards, and information technology organization. Membership provides stakeholders with an opportunity to influence key activities as they develop.

Other IMPC governing bodies include a panel of scientific consultants, Finance Committee, Communications Working Group, Phenotyping Steering Group, Production Steering Group, Data Analysis Advisory Committee, Statistics Technical Group, MTA and Line Exchange, iMits Steering Group, and IMPC Secretariat.

Financing

IMPC is funded by funders’ membership fees of £50,000. Funding members include Medical Research Council, National Institutes of Health, Wellcome Trust, Genome Canada, Canadian Institutes of Health Research, and European Commission. 

Sponsors & Partners

 

Australian Phenomics Network

Baylor College of Medicine

Charles River Laboratories

Children’s Hospital of Oakland Research Institute

CNR Monterotondo

Czech centre for Phenogenomics

EBI

Helmholtz Zentrum Munich (GMC)

Institut Clinique de la Souris

Jackson Lab

Korean Mouse Phenotype Consortium

MARC, Nanjing

MRC Harwell

National Institutes of Health

NLAC NARCLabs, Taiwan

Riken BRC (JMC)

Sanger Institute

Toronto Centre for Phenogenomics

University of California, Davis


Last Updated: 05/24/2016

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