International Partnership for Microbicides (IPM)

At a Glance
  • Status: Active Consortium
  • Year Launched: 2002
  • Initiating Organization: International Partnership for Microbicides
  • Initiator Type: Third-party organization
  • Disease focus:
    Human Immunodeficiency Virus (HIV)
  • Location: International

Abstract

International Partnerships for Microbicides (IPM) is dedicated to providing women with affordable and self-initiated human immunodeficiency virus (HIV)-prevention strategies they can use to protect their own health. Founded in 2002 as a product development partnership, IPM has become an important partner in the microbicide field.

Mission

IPM’s work is guided by a singular global health mission: (a) provide women with safe, effective, and affordable products they can use to protect themselves against HIV infection and (b) make these products available as quickly as possible where the need is most urgent.

IPM is developing microbicides that are based on the same types of antiretroviral (ARV) drugs that are already being used successfully to treat HIV/AIDS and to prevent mother-to-child transmission and that have been shown in various studies to prevent HIV when used consistently.

IPM’s work, like that of other nonprofit organizations in the field, is focused on turning that promise into a scientific reality.

Consortium History

2002: IPM founded

Structure & Governance

IPM’s Board of Directors (BOD) oversees the organization’s strategic planning, operations, and finances.
Board members have extensive experience in public health, HIV prevention, pharmaceutical development, economic development, healthcare financing, and government operations in developing and developed countries.

The current Board consists of 12 members, representing countries in Africa, Asia, Europe, and North America, who work in academia, government, and the for-profit and nonprofit private sectors. Each member serves on a volunteer basis for three-year terms. IPM’s chief executive officer serves as an ex officio nonvoting member of the Board.

IPM’s Scientific Advisory Board (SAB) was created in 2002 to provide ongoing, high-level, scientific advice to IPM’s staff and BOD. The scientific agenda is based on a set of decision-making criteria first approved by the SAB in 2003. The original SAB did not meet regularly, but IPM established an Executive Committee of its SAB to convene annually, beginning in 2006. In 2009, the SAB created two subcommittees, with ad hoc subcommittees to be formed if product development and clinical activities and timelines require more defined expert discussion. The SAB consists of members with expertise in drug development, HIV and ARV science, microbicide development, clinical evaluation, delivery system expertise, regulatory knowledge, and other relevant areas.

IPM’s BOD reviews, approves, and updates, as needed, the “Terms of Reference for the SAB” and is consulted on SAB composition and leadership.

IPM is committed to conducting its work in an ethical manner. IPM’s Foreign Corrupt Practices Act Policy can be found on its website.

Financing

IPM is supported by a diverse donor base. Major donors who have contributed to IPM since its founding in 2002 include Belgian Development Cooperation, Bill & Melinda Gates Foundation, Canadian International Development Agency, Ministry of Foreign Affairs of Denmark, Flanders Department of Foreign Affairs, Ministry of Foreign and European Affairs of France, Germany Federal Ministry for Economic Cooperation and Development, Irish Aid Department of Foreign Affairs, MAC AIDS Fund, Norwegian Ministry of Foreign Affairs, The Netherlands Ministry of Foreign Affairs, OPEC Fund for International Development, The Rockefeller Foundation, Spain Ministry of Foreign Affairs and Cooperation, Sweden Ministry of Foreign Affairs, Swedish International Development Cooperation Agency, United Kingdom Department for International Development, United Nations Population Fund, U.S. Agency for International Development, U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), and World Bank.

Impact/Accomplishment

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy.

IPM announced in May 2014 that it received exclusive worldwide rights to a promising HIV prevention medicine called dapivirine from Janssen R&D Ireland, one of the Janssen Pharmaceutical Companies of Johnson & Johnson. The agreement expands on IPM’s existing rights to develop, manufacture, and commercialize dapivirine-based products for use by women in developing countries and will now give women in developed countries access to products containing dapivirine, such as a vaginal ring that combines dapivirine and a contraceptive.

Since IPM’s inception in 2002, its pipeline has included products based on ARVs — the same types of drugs that have proven successful in treating HIV/AIDS and preventing mother-to-child transmission in millions of people around the world. The pipeline of ARV compounds at IPM is a result of its partnerships with pharmaceutical companies. Through royalty-free licensing agreements for seven ARVs or active pharmaceutical ingredients and exclusive worldwide rights for one ARV called dapivirine, IPM has access to an array of drugs with a variety of mechanisms of action against HIV infection.

IPM’s clinical trials are carried out sequentially: first to determine the safety of a product and then to test its efficacy or ability to prevent HIV infection. Its initial safety trials, Phase I trials, involve small numbers of women under carefully controlled clinical conditions. Expanded safety trials, Phase I/II, are then conducted to gain additional safety data among more participants over longer periods of time. When the safety trials are complete, longer-term safety and efficacy trials are conducted. IPM has carried out 24 clinical trials to date.

Points of Contact

8401 Colesville Rd., Ste. 200, Silver Spring, MD 20910

Sponsors & Partners

ABL, Inc.

Advanced Biosciences Laboratory

AIDS-Fondet

Albert Einstein College of Medicine

Almac

AVAC

Bristol-Myers Squibb

Catalent

CHAARM

CONRAD

Desmond Tutu HIV Foundation

Deutsche Stiftung Weltbevoelkerung (DSW)

Drexel University

Equilibres et Populations

Fisher Clinical Services

Gilead

Global Campaign for Microbicides

Global Health Technologies Coalition

Gynuity Health Projects

Huntingdon Life Sciences

Imperial College

Imquest Biosciences

Interagency Coalition on AIDS and Development

Janssen Sciences Ireland (UC)

Kenya Medical Women’s Association

Madibeng Centre for Research

Magee-Womens Research Institute

Maternal, Adolescent, and Child Health, Department of Obstetrics and Gynaecology, University of the Witwatersrand

Merck

Microbiological Environments

MRC/UVRI Uganda Research Unit on AIDS

Ndlovu Care Group

Omnichem

Open Society Initiative for Southern Africa

Parexal

Particle Sciences, Inc.

Penn Pharma

PharmaVize

Planeta Salud

Population Council

Prevention of HIV/AIDS Project (PHIVA)

Qhakaza Mbokodo

QPharma

Queens University- Belfast

SENSOA

Sex og Politikk

Southern Africa AIDS Trust (SAT)

Tandem Labs

ViiV Healthcare


Last Updated: 04/15/2016

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