Mechanisms of the Development of Allergy (MeDALL)


At a Glance
  • Status: Completed Consortium
  • Year Launched: 2010
  • Initiating Organization: European Commission Seventh Framework Programme (FP7)
  • Initiator Type: Government
  • Disease focus:
    Allergies
  • Location: Europe
meALL

Abstract

The Mechanisms of the Development of ALLergy (MeDALL) consortium aims to generate novel knowledge on the mechanisms of initiation of allergy from early childhood to young adulthood, in order to propose early diagnosis, prevention, and targets for therapy. MeDALL encompasses 23 public and private institutions, including three European small to medium-sized enterprises (SMEs), who will combine their efforts to contribute to the elucidation of the mechanisms of allergy-associated diseases. MeDALL is gathering leading experts in clinical allergy (i.e., allergology, asthma, atopic dermatitis, food allergy, pediatrics), epidemiology, genetics, immunology, molecular biology, allergen biochemistry, and bioinformatics.

Mission

MeDALL aims to generate novel knowledge on the mechanisms of initiation of allergy from early childhood to young adulthood, in order to propose early diagnosis, prevention, and targets for therapy. A novel definition of phenotypes of allergic diseases and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic phenotypes.
 
To achieve its objectives, MeDALL is organized into 12 integrated Work Packages (WPs), specifically designed to foster transnational collaboration between experts from different aspects of the development of allergy-associated diseases, as well as integration via the inclusion of leading scientists and SMEs in the field.

Consortium History

January 2012: Annual meeting
January 2013 Annual meeting
January 2014: Annual meeting
May 2015: Final annual meeting

Financing

MeDALL is a collaborative project supported by the European Union under the Health Cooperation Work Programme of the Seventh Framework Programme (grant agreement no. 261357).

Impact/Accomplishment

In 2015, two new MeDALL papers were published. In one study MeDALL researchers assessed more than 17,000 children at four years and 14,500 at eight years from 12 ongoing European population-based birth cohort studies conducted in Denmark, France, Germany, Italy, Netherlands, Norway, Spain, and Sweden. The study recorded information on allergic diseases from parents and doctors and collected IgE antibodies to six allergens in blood samples (sensitization). The study showed at the population level, asthma, rhinitis, and eczema can be classified together as an allergic comorbidity cluster (Garcia-Aymerich J et al. Allergy, 2015 Apr 30. doi: 10.1111/all.12640. [Epub ahead of print]).
 
In another study, a review of MeDALL results and the literature puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re-occurrence of foetal Type 2 signaling (Bousquet J et al. Allergy. 2015 Apr 24. doi: 10.1111/all.12637. [Epub ahead of print]).

Points of Contact

Project Coordinator
Jean Bousquet
CESP U1018 INSERM
16 Av Paul Vaillant Couturier
94807 Villejuif Cedex - France
email: jean.bousquet@inserm.fr
 
Scientific Coordinator
Josep M. Antó
Centre de Recerca en Epidemiologia
Ambiental (CREAL)
Parc de Recerca Biomèdica
de Barcelona (despatx 192)
Doctor Aiguader 88
08003 Barcelona - Spain
email: gpunyet@creal.cat
 
Project Manager
Delphine Smagghe
Inserm Transfert
Paris Biopark
7 Rue Watt 75013 Paris - France
email: delphine.smagghe@inserm-transfert.fr

Sponsors & Partners

Arizona Board of Regents, University of Arizona

Azienda sanitaria locale Roma

Biomax Informatics AG

Biomay AG

Bradform Teaching Hospitals Foundation Trust

Centre National de la Recherche Scientifique (CNRS)

Charite – Universitatsmedizin Berlin

European Federation of Allergy and Airways Diseases Patients Association

Fundacio Centre de Recerca en Epidemiologia Ambiental (CREAL)

Helmholtz Zenstrum Munchen, German Research Centre for Environmental Health

Helsinki University Central Hospital

Inserm-Transfert SA

Institut National de la Sante et de la Recherche Medicale (INSERM)

Karolinska Institute

Medical University of Lodz

Medical University of Vienna

Odense University Hospital

Onmedic Networks, S.L.

Swiss Institute of Allergy and Asthma Research (SIAF)

University Medical Center Groningen (UMCG)

University of Ghent

University of Oslo

University of Utrecht


Last Updated: 04/22/2016

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