Top Industry Pharma (TI Pharma)


At a Glance
  • Status: Active Consortium
  • Year Launched: 2006
  • Initiating Organization: Top Industry Pharma
  • Initiator Type: Nonprofit foundation
  • No disease focus
  • Location: International

Abstract

Top Institute Pharma (TI Pharma) initiates and manages drug development consortia that involve the pharmaceutical industry, academia, and the Dutch government. The aim of all of the consortia is to conduct precompetitive research while strengthening the Netherlands’ international reputation for drug development. The focus of all their consortia is on five therapeutic areas: autoimmune diseases, cardiovascular diseases, cancer, infectious diseases, and diseases of the brain.

Mission

TI Pharma was established to initiate and manage drug development consortia to advance the competitiveness of the Netherlands in the pharmaceutical sector, complementing similar Netherlands-based, public-private initiatives to advance diagnostics (Center for Translational Molecular Medicine, CTMM) and devices (BioMedical Materials program, BMM). TI Pharma consortia aim to improve the efficiency of the drug-development process, with a focus on advancing regulatory science. In addition to research, TI Pharma also has objectives to train and educate scientists in the Netherlands on the drug discovery and development processes, as well as on entrepreneurship. 

The consortia are focused on addressing therapeutic areas that are listed as priority areas by the World Health Organization. These include autoimmune diseases, cardiovascular diseases, cancer, infectious diseases, and diseases of the brain. In addition to therapeutic focus, the consortia are also focused on enabling therapeutic target discovery, validation, and animal models; lead selection and in silico modeling; predictive drug disposition and toxicology; biomarkers and biosensors; drug formulation, delivery, and targeting; and production technologies.  

Consortium History

2005: Twenty-seven projects selected in first call for proposals
2006: Eighteen projects selected in second call for proposals

Structure & Governance

The TI Pharma strategy is divided into two stages. The first stage, which occurred in 2006, coordinated the Dutch universities and pharmaceutical companies in collaborative research programs (each project is required to have at least three research partners, one of which must represent the industrial or academic community). The second stage started in 2007 with an aim to further increase European involvement via the Seventh Framework Programme, while simultaneously incentivizing participation from U.S.-based pharmaceutical companies.

Participants include all Dutch universities and academic medical centers, more than 30 industrial partners, small-to-medium sized companies, and representatives from the Dutch Medicines Evaluation Board (Netherlands regulatory body for drugs).

Financing

The Dutch government provides €30 million in annual funding, which is matched through financial and in-kind contributions by industry and academia (€15 million, each per year), for four to six years.

Intellectual Property

The TI Pharma consortia follow general principles that govern intellectual property agreements. The principles can be summarized as the following:
Each consortium has one patent coordinator.

Data Sharing

The level and method of data sharing is dependent on the scientific goals of the consortium.

Impact/Accomplishment

TI Pharma was able to start and manage 96 research consortia within its first six years. Results of the consortia are described in the annual report, which can be found here

Points of Contact

TI Pharma
PO Box 142
2300 AC Leiden
The Netherlands
phone: 071-332-2030
fax: 071-332-2031
email: info@tipharma.com

Sponsors & Partners

3D-PharmXchange

Abbott Laboratories

Abbvie/Shire

Academic Medical Center Amsterdam

Actelion

Aeon Astron Europe

Agamyxis

Agendia

Amgen, Inc.

Arcarios

Astellas Pharma Inc.

AstraZeneca

Batavia Bioservices

Bio Detection Systems

Bio Medical Materials Program

Bioceros

Biomade Technology

BioMarin

Bionovion

CardioGenx

Center for Translational Molecular Medicine

Centocor

Centre for Human Drug Research (Netherlands)

Danone Research

DC Prime

Drugs for Neglected Diseases Initiative

DSM Biomedical

Dutch Polymer Institute

Eli Lilly & Co.

Erasmus University Rotterdam

Fabry Support & Informatie Groep Nederland

Feyecon

Foundation for Innovative New Diagnostics

Galapagos

Galapagos/BioFocus

GE Healthcare

GlaxoSmithKline

Glycostem Therapeutics

Healthcare Insurance Board (Netherlands)

Holst Centre

HQ Medical

Hubrecht Institute

InteRNA Technologies

IOTA Pharmaceuticals

IQ Corporation/IQ Therapeutics

ISA Pharmaceuticals

Isconova

Jan van Es Institute

Johnson & Johnson

KNMP/WINap

Lead Pharma

Leiden University

Life Sciences & Health

Life Sciences & Health cluster organization

LifeAssay Diagnostics

Lundbeck A/S

Maastricht University

Madam Therapeutics

Magistro

Medicines Evaluation Board

Mercachem

Merck Sorono/EMD Serono

Mucosis

Mymetics

Nefarma

Netherlands Cancer Institute

Netherlands Institute for Health Services Research

Netherlands Institute for Metal Research

Netherlands Institute for Neuroscience

Netherlands Organisation for Applied Scientific Research (TNO)

Netherlands Vaccine Institute 

NOTOX

Nycomed

OctoPlus

PamGene

Pansynt

Pepscan Presto

Percuros

Pfizer, Inc.

Pivot Park Screening Centre

PRA International

Prosensa Therapeutics

PROXY Laboratories

Radboud University Nijmegen

Royal Tropical Institute (KIT)

Sanaria

Sanofi S.A.

Sanofi/Genzyme Corp

Syncom

Synvolux Therapeutics

Telematica Instituut

TropIQ

UbiQ

University Medical Center Groningen

University Medical Center Utrecht

University of Amsterdam

University of Bern

University of Groningen

Utrecht University

Vaxinostics

Vereniging Spierziekten Nederland (VSN)

Vereniging Volwassenen, Kinderen en Stofwisselingsziekten (VKS)

Vertex Pharmaceuticals Incorporated

ViroClinics

VU University Amsterdam

Wageningen Centre for Food Sciences

Wageningen University and Research Center  

Xendo

ZonMW


Last Updated: 04/08/2016

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