Towards novel translational safety biomarkers for adverse drug toxicity

At a Glance
  • Status: Completed Consortium
  • Year Launched: 2007
  • Initiating Organization: TI Pharma
  • Initiator Type: Nonprofit foundation
  • No disease focus
  • Location: International



This project studies the metabolic effects of eight drugs (among which are paracetamol and diclofenac) with known side effects in the liver. By looking into the mechanics on a level ranging from the molecule to the patient, the researchers in this project aim to find biomarkers and develop tools for the early prediction of side effects of drugs. One of the breakthroughs in the project is the discovery that a person’s genetic profile appears to be one of the mechanics that have an influence on the resistance to adverse drug reactions. The ability to identify adverse effects in an early stage will prevent much discomfort in patients and economic loss.


This project resulted in five Ph.D. theses:

Sponsors & Partners


BioDetection Systems BV

 BioFocus DPI

Leiden University




Pepscan Presto BV

Radboud University Nijmegen Medical Centre

University of Gronigen

Utrecht University

VU University Amsterdam

Last Updated: 04/07/2016

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