Alzheimer’s Disease Genetics Consortium (ADGC)
Research Areas
At a Glance
- Status: Completed Consortium
- Year Launched: 2009
- Initiating Organization: University of Pennsylvania
- Initiator Type: Academia
- Disease focus:
Alzheimer's Disease - Location: North America
Abstract
The Alzheimer’s Disease Genetics Consortium (ADGC) was founded to conduct genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD). This five-year consortium, spanning universities from both Europe and the United States, will combine the knowledge, staff, and resources of four existing consortia that conduct research on Alzheimer's disease genetics.
Mission
ADGC’s goal is to identify genetic variants associated with risk for Alzheimer’s disease (AD). The effort leverages the current knowledge that genetic factors play an important role in the development of AD. For example, it has been shown through familial aggregation studies that first degree relatives of probands with AD are more likely to have or develop AD compared to relatives of controls. Twin studies show a higher concordance of AD among monozygotic compared to dizygotic twins, with heritability estimates of 60% to 80%. This five-year consortium, spanning universities from both Europe and the United States, will combine the knowledge, staff, and resources of four existing consortia that conduct research on Alzheimer's disease genetics.
Consortium History
2009: Gerard Schellenberg, PhD, professor of pathology and laboratory medicine, received an $18.3 million, five-year grant from the National Institute on Aging to lead ADGC.
Structure & Governance
An Executive Committee oversees ADGC and makes major decisions on administrative and scientific matters by voting. Executive Committee members include key members (principal investigators [PI] and Co-PIs) of the ADGC research proposal and representatives from institutions that contribute a major portion of samples to the ADGC study.
ADGC is supported by six subcommittees, all of which report to the Executive Committee:
Financing
ADGC is funded by a grant from the National Institute on Aging (PI, Gerard D. Schellenberg; UO1AG032984), an $18.3 million, five-year research grant to conduct GWAS to identify genes associated with an increased risk of developing LOAD.
Data Sharing
To request or submit data to ADGC, please contact: data@mail.med.upenn.edu
Impact/Accomplishment
Since 2010, 25 ADGC reports/papers have been published.
Links/Social Media Feed
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Homepage |
Points of Contact
For queries and comments regarding ADGC, please contact:
Laura Cantwell
Department of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
422 Curie Boulevard
Philadelphia, PA 19104-6082
email: Lcant@mail.med.upenn.edu
For queries and comments on the ADGC website, please contact:
Otto Valladares
email: ottov@mail.med.upenn.edu
Sponsors & Partners
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Banner Alzheimer’s Institute |
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Boston University |
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Children’s Hospital of Philadelphia |
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Columbia University |
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Duke University Medical Center |
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Einstein |
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Emory University |
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Florida Alzheimer’s Center |
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Genentech |
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Indiana University |
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Johns Hopkins |
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Lou Ruvo Brain Institute |
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Massachusetts General |
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Mayo Clinic |
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Mayo Clinic College of Medicine |
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Mayo Clinic Florida |
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Mount Sinai School of Medicine |
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National Alzheimer’s Coordinating Center |
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National Institute on Aging |
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National Institutes of Health |
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New York University |
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Northwestern University Medical School |
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Oregon Health Sciences University |
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Rush University Medical Center |
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Stanford University |
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The Hospital for Sick Children |
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University of Alabama |
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University of Arkansas for Medical Sciences |
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University of California, Davis |
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University of California, Irvine |
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University of California, Los Angeles |
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University of California, San Diego |
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University of California, San Francisco |
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University of Chicago |
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University of Gothenburg |
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University of Kentucky |
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University of Miami |
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University of Michigan |
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University of North Texas |
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University of Pennsylvania |
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University of Pittsburgh |
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University of San Diego |
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University of Southern California |
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University of Texas Southwestern |
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University of Toronto |
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University of Virginia |
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University of Washington |
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USC, Los Angeles |
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Vanderbilt University |
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Wake Forest University |
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Washington University |