Antibody Derivatives As Molecular Agents for Neoplastic Targeting Consortium (ADAMANT)
Research Areas
At a Glance
- Status: Completed Consortium
- Year Launched: 2008
- Initiating Organization: The European Union Seventh Framework Programme
- Initiator Type: Government
- Disease focus:
Cancers - Location: Europe
Abstract
Under the umbrella of ADAMANT (Antibody Derivatives As Molecular Agents for Neoplastic Targeting), nine teams from six European countries -comprising research institutes, universities, hospitals, foundations, and small enterprises- pursued research aimed at the discovery of improved anticancer therapies, which rely on the antibody-based delivery of cytotoxic agents, radionuclides or immunostimulatory cytokines to tumour cells. The premise guiding the ADAMANT research consortium’s efforts is that this targeted approach of administration spares normal tissues, reduces toxicity, and achieves unprecedented efficacy. The project has built on a multidisciplinary approach involving an already consolidated team of chemists, pharmacologists, clinicians, and clinical researchers, and endeavoured to bring the selected antibody + drug complexes from the basic research setting to the initial phases of clinical investigation.
Mission
Bearing in mind the 7-10 year time span normally needed to move a prospective agent through the pipeline and into clinical use, the benchmark of the project’s success - be the transfer of at least one antibody-based tumour targeting agent to initial clinical studies - has been reached.
Consortium History
Began on April 1, 2008.
Structure & Governance
The project is governed by a consolidated team of chemists, pharmacologists, clinicians, and clinical researchers that represent different participating organizations
Financing
Three-year € 3,000,000 research project funded under the European Union’s Seventh Framework Programme (FP7)
Intellectual Property
To view the research performed by ADAMANT Consortium, you must be a member
Impact/Accomplishment
For a summary of the final report, published in 2011, click here
Links/Social Media Feed
Homepage |
http://www.adamant-fp7.eu/index.php |
Points of Contact
For information regarding ADAMANT, contact The European Union Commission directly
Sponsors & Partners
Raffaella Giavazzi, Coordinator, Istituto di Ricerche Farmacologiche Mario Negri |
Dario Neri, ETH Zurich |
Alex Berndt, Friedrich-Schiller-Universität |
Matteo Zanda, Kemotech Srl |
Eveline Trachsel, Philochem |
Silvia Marsoni, SENDO Foundation |
Barbara Pedley, University College London |
Vincent Castronovo, Universitè de Liège |
Guus Van Dongen, VU University Medical Center |