CFTR 3D-Structure Consortium

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At a Glance
  • Status: Active Consortium
  • Initiating Organization: The Cystic Fibrosis Foundation
  • Initiator Type: Nonprofit foundation
  • Disease focus:
    cystic fibrosis

Abstract

CFTR 3D-Structure Consortium is a research consortium of the Cystic Fibrosis Foundation.  The CF Foundation is the world's leader in the search for a cure for cystic fibrosis, and nearly every CF-specific drug available today was made possible with their financial support. The CF Foundation supports a wide range of innovative research programs to discover and develop new and effective CF therapies. By harnessing the best minds in science and medicine, the Foundation has made tremendous progress in understanding and treating the disease, and they continue to pursue every opportunity that could help people with CF live longer and healthier lives.

Mission

Consortium members work together to expand knowledge of the structure, the energetics and the mechanism of CFTR function. The Consortium's goals are to:

Obtain high-quality protein reagents for full-length CFTR and CFTR structural domains

Characterize the physicochemical properties of CFTR and CFTR structural domains

Obtain high-resolution 3D-structures of interactions between structural domains of CFTR

Obtain high-resolution 3D-structures of the full length CFTR protein

Obtain knowledge of the binding location and energetic/folding consequences of CFTR modulators on CFTR or CFTR domains

Consortium History

For a full history of the Cystic Fibrosis Foundation, click here

Structure & Governance

Members of the Board of Trustees (of the Cystic Fibrosis Foundation) hold a legal and fiduciary responsibility for the operations of the Foundation.

Their Board of Trustees is a diverse group of 16 independent members plus the CEO, who bring a variety of experiences and expertise to the governance of the CF Foundation.

Financing

The CF Foundation is a donor-funded, 501(c)(3) nonprofit that is fully accredited by the Better Business Bureau's (BBB) Wise Giving Alliance program.

Points of Contact

Cystic Fibrosis Foundation (national headquarters)
6931 Arlington Road, 2nd floor
Bethesda, Maryland 20814

Local: 301-951-4422
Toll free: 800-FIGHT-CF (800-344-4823)

Email: info@cff.org

Sponsors & Partners

Christie Brouillette, Ph.D. (University of Alabama at Birmingham)

Larry DeLucas, Ph.D. (University of Alabama at Birmingham)

Robert Ford, Ph.D. (The University of Manchester)

Julie Forman-Kay, Ph.D. (The Hospital for Sick Children)

John F. Hunt, Ph.D. (Columbia University)

John Kappes, Ph.D. (University of Alabama at Birmingham)

John Riordan Ph.D. (University of North Carolina at Chapel Hill)

Hanoch Senderowitz, Ph.D. (Bar Ilan University)

Patrick Thibodeau, Ph.D. (University of Pittsburgh)

Ina Urbatsch, Ph.D. (Texas Tech University Health Sciences Center)

Last Updated: 06/19/2017
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