Chronic Graft Versus Host Disease (cGVHD) Consortium
Research Areas
At a Glance
- Status: Active Consortium
- Year Launched: 2009
- Initiating Organization: NIH Rare Disease Clinical Research Network
- Initiator Type: Government
- Rare disease
- Disease focus:
Immune Related Disorders After Allogenic Hematopoietic Cell Tran - Location: North America
Abstract
The Chronic Graft Versus Host Disease (cGVHD) Consortium is an integrated group of academic medical centers, patient support organizations, and clinical research resources dedicated to conducting clinical research in different immune-mediated disorders after allogeneic hematopoietic cell transplantation and to improving the care of patients affected by these disorders.
Mission
The cGVHD Consortium seeks to decrease illness, limit disability and prevent death for patients who develop immune-mediated complications after allogeneic hematopoietic cell transplantation.
Goals of the consortium are as follows:
Structure & Governance
This consortium is part of the Rare Diseases Clinical Research Network (RDCRN), an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Sciences (NCATS). The RDCRN is designed to advance medical research on rare diseases by providing support for clinical studies and facilitating collaboration, study enrollment, and data sharing. Through the RDCRN consortia, physician scientists and their multidisciplinary teams work together with patient advocacy groups to study more than 200 rare diseases at sites across the nation.
Funding and scientific oversight for the RDCRN are provided by NCATS and 10 National Institutes of Health (NIH) components: Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Heart, Lung and Blood Institute; National Institute of Allergy and Infectious Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; and Office of the Director. In addition, patient advocacy groups provide funds for many of the projects.
Financing
Funded by NIH, the cGVHD Consortium is part of the RDCRN.
Impact/Accomplishment
Chronic Graft versus Host Disease Projects:
6501: Longitudinal Study of Immune Mediated Disorders after Allogeneic HCT Protocol (Immune Mediated Disorders after Allo-HCT)
6504: A Phase II Study of Bandage Lenses for Ocular Graft-versus-host Disease after Allogeneic Hematopoietic Cell Transplantation
Cutaneous Sclerosis
6502: A Randomized Phase II Study of Imatinib and Rituximab for Cutaneous Sclerosis after Allogeneic Hematopoietic Cell Transplantation
Bronchiolitis Obliterans
6503: Targeted Therapy of Bronchiolitis Obliterans Syndrome (BOS)
Links/Social Media Feed
Homepage |
Points of Contact
Sponsors & Partners
Cleveland Clinic |
Dana Farber Cancer Institute |
Fred Hutchinson Cancer Research Center |
H. Lee Moffitt Cancer Center |
Mayo Clinic, Scottsdale, AZ |
Medical College of Wisconsin |
National Cancer Institute |
Roswell Park Cancer Center |
Stanford University |
University of Minnesota |
University of North Carolina |
Vanderbilt University |
Washington University, St. Louis |
Weill Cornell Medical College |