CTFR Folding Consortium


At a Glance
  • Status: Active Consortium
  • Year Launched: 2009
  • Initiating Organization: The Cystic Fibrosis Foundation
  • Initiator Type: Nonprofit foundation
  • Disease focus:
    cystic fibrosis
  • Location: North America

Abstract

CFTR Folding Consortium is a research consortium of the Cystic Fibrosis Foundation.  The CF Foundation is the world's leader in the search for a cure for cystic fibrosis, and nearly every CF-specific drug available today was made possible with their financial support. The CF Foundation supports a wide range of innovative research programs to discover and develop new and effective CF therapies. By harnessing the best minds in science and medicine, the Foundation has made tremendous progress in understanding and treating the disease, and they continue to pursue every opportunity that could help people with CF live longer and healthier lives.  The CFTR Folding Consortium is composed of a group of investigators dedicated to developing and distributing reagents and methods to facilitate a practical understanding of why disease-associated CFTR mutants misfold and how to correct these defects.  These methods and reagents are made available to researchers focused on these two goals.  Investigators who utilize these resources are required to provide feedback on their utility and are asked to make available any new, improved reagents or methods they developed from them.

Mission

Understanding how CFTR mutations result in a misfolded and/or non-functional protein is important for the development of new therapies that can correct these abnormalities to restore functional CFTR in people with CF. The focus of the CFTR Folding Consortium is to:

Understand the process of CFTR folding and trafficking.

Develop and distribute reagents (antibodies and proteins) and methods to facilitate a practical understanding of why disease-associated CFTR mutant misfolds and how to correct these defects.

Consortium History

For a full history of the Cystic Fibrosis Foundation, click here

Structure & Governance

Members of the Board of Trustees (of the Cystic Fibrosis Foundation) hold a legal and fiduciary responsibility for the operations of the Foundation.

Their Board of Trustees is a diverse group of 16 independent members plus the CEO, who bring a variety of experiences and expertise to the governance of the CF Foundation.

Points of Contact

Cystic Fibrosis Foundation (national headquarters)
6931 Arlington Road, 2nd floor
Bethesda, Maryland 20814

Local: 301-951-4422
Toll free: 800-FIGHT-CF (800-344-4823)

Email: info@cff.org

Sponsors & Partners

William E. Balch, Ph.D. (The Scripps Research Institute)

Ineke Braakman, Ph.D. (Urecht University)

Jeffery Brodsky, Ph.D. (University of Pittsburgh)

Raymond Frizzell, Ph.D. (University of Pittsburgh School of Medicine)

William Guggino, Ph.D. (Johns Hopkins University)

Gergely Lukacs, M.D., Ph.D. (McGill University)

Harvey B. Pollard, M.D. (Uniformed Services University of the Health Sciences)

William R. Skach, M.D. (Oregon Health & Sciences University)

Eric. J. Sorscher, M.D. (The University of Alabama at Birmingham)

Philip J. Thomas, Ph.D. (University of Texas Southwestern Medical Center at Dallas)


Last Updated: 06/19/2017

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