European Microbicides Project (EMPRO)


At a Glance
  • Status: Completed Consortium
  • Year Launched: 2004
  • Initiating Organization: European Commission Sixth Framework Programme (FP6)
  • Initiator Type: Government
  • Disease focus:
    HIV/AIDS
  • Location: Europe

Abstract

This proposal aims to develop new topical microbicides that block entry of HIV at mucosal sites with the aim of establishing a pipeline of candidate microbicides while taking selected microbicides through Phase I clinical trial. The proposed programme will bring together leading European experts in this field to work on an integrated programme of research. Members of the consortium have extensive expertise in analyses of molecular structure, molecular interactions, investigation of mechanisms of HIV infection, testing efficacy in animal models, development of methods for large-scale production of microbicides, mucosal delivery, and the conduct of clinical trials particularly in developing countries. The proposal builds on this strength and describes novel approaches to develop new microbicides. Novel molecules and combinatorial peptide, polypeptide, and oligosaccharide libraries will be screened for inhibitors that are specifically targeted to viral envelope proteins or host receptors.

Mission

Microbicidal efficacy of inhibitors will be rigorously tested in vitro and the most promising will be formulated and tested in animal models. The developmental process for candidate agents will be target-driven according to an established preclinical selection algorithm designed to fast track the most promising candidates and/or combination. This process will not be carried out in isolation from the rest of the International field, particular emphasis will be placed on development of compounds demonstrating synergistic activity with first generation compounds further ahead in the developmental process. The programme will operate like a virtual company allowing strategic developmental and budgetary decisions to be continuously reviewed. As well as identifying novel candidate microbicides, the programme should provide a rational basis for the design of second or third generation microbicides.

Structure & Governance

The European Microbicides Project is a project funded by the European Union and driven by the European Commission’s Community Research and Development Information Service (CORDIS).

Financing

The consortium was funded under the European Commission’s “Community Research and Development Information Service (CORDIS),” for just over 15 million euros.  

Points of Contact

KING'S COLLEGE, London
Strand
LONDON
United Kingdom
Administrative contact: Charles KELLY
Tel.: +44-2079554966
Fax: +44-2079554455

Sponsors & Partners

ST. GEORGE'S HOSPITAL MEDICAL SCHOOL

KATHOLIEKE UNIVERSITEIT LEUVEN

INSERM ADR PARIS

CARBOHYDRATE SYNTHESIS LIMITED

UNIVERSITA DEGLI STUDI DI MILANO

ABLYNX N.V.

ISTITUTO SUPERIORE DI SANITÀ

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

COMMISSARIAT À L'ENERGIE ATOMIQUE

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS

PEPSCAN SYSTEMS BV

GLYCORES 2000 SRL

UNIVERSITÀ DEGLI STUDI DI SIENA

TECHNISCHE UNIVERSITÄT MÜNCHEN

UNIVERSITY OF STELLENBOSCH

PRINCE LEOPOLD INSTITUTE OF TROPICAL MEDICINE, ANTWERP

CENTRE INTERNATIONAL DE RECHERCHES MÉDICALES DE FRANCEVILLE

BIOZENTRUM DER UNIVERSITÄT BASEL

UNIVERSITY COLLEGE LONDON

TIBOTEC PHARMACEUTICALS LTD

THE UNIVERSITY OF READING

UNIVERSITY OF YORK

COUNCIL FOR SCIENTIFIC & INDUSTRIAL RESEARCH

UNIVERSITY UTRECHT, DEPARTMENT OF BIOLOGY

POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES - CIC BIOMAGUNE

PEPSCAN THERAPEUTICS BV

QUEEN'S UNIVERSITY BELFAST


Last Updated: 06/19/2017

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