Manchester Chemical Biology Network (MCBN)
Research Areas
At a Glance
- Status: Completed Consortium
- Year Launched: 2011
- Initiating Organization: University of Manchester
- Initiator Type: Academia
- No disease focus
- Location: Europe
Abstract
The Manchester Chemical Biology Network (MCBN) provides a unique cross-disciplinary forum for uniting scientists from across chemical, biological, and medical science with user organizations.
Mission
This collaborative network focuses on the following areas:
- Computational and chemical tools
- Chemical systems biology
- Target elucidation and modulation
- Biopharmaceuticals and nanomedicine
Impact/Accomplishment
The MCBN network has funded a number of small projects and opportunities to increase collaborations in the field of chemical biology. Funded projects include:
Andrew Doig, Ewan Blanch (UoM), and Lorna Kettle (Intertek)
Development of protocols for protein structure analysis from IR spectra
Michelle Webb (UoM) and Ian Taylor (Mill Hill)
Understanding the mechanistic detail of triphosphohydrolase activity of SAMH1
Elena Bichenkova, Richard Bryce (UoM), Alex Breeze, and Andrew Thomas (AZ)
Development of selective, cell-permeable inhibitors of protein tyrosine
Elena Bichenkova (UoM), John Bremner, and Catherine McKeen (LinkTech)
Exciplex-based nanoparticles for potential biomedical and clinical applications
Jason Micklefield (UoM) and Barry Wilkinson (Biotica)
Alkyltransferases for selective alkylation of rapalogs
Alexander Golovanov (UoM) — collaborative meeting
Complex formulation of biopharmaceuticals
Ben Sattelle, Andrew Almond (UoM), Martin Packer (AZ), and Andy Grant (AZ)
Priming the use of GPU-accelerated equilibrium simulations in drug discovery
John Helliwell (UoM), McKenzie, Chayen and Garzoni (Imperial College, P-Cube EMBL) Research visit Heparanase expression in insect cells, purification and crystallization
Steve Prince and Ewan Blanch (UoM)
Mapping vibration modes in the Gly-Tyr-Gly peptide
Lydia Tabernero, Andrew Doig (UoM), and Farid Khan (Lumophore Bio-Tech)
New strategies to cure tuberculosis
Richard Henchman (UoM) and Richard Law (Evotec Drug discovery) Research visit
Determination of water’s contribution to protein-ligand binding
Richard Bryce (UoM, Chem) Conference funds: Computational Chemical Biology
Probing biology with in silico tools: Thursday, 13th September 2012 in the MIB
Roger Whitehead (Chem) and Viki Allan (FLS)
Research project on “The synthesis and biological assessment of inhibitors of dynein, a “molecular motor” responsible for the intra-cellular transport of a variety of “cargoes”
Links/Social Media Feed
Homepage |
Sponsors & Partners
AstraZeneca |
Biotica |
GlaxoSmithKline |
Imagen Biotech |
Manchester Biomedical Research Centre |
Manchester Institute of Biotechnology |
Morvus |
Oxyrane |
Peakdale Molecular |
Pfizer |
Senexis |
Syngenta |
University of Manchester |