MM4TB (More Medicines for Tuberculosis)
Research Areas
At a Glance
- Status: Completed Consortium
- Year Launched: 2011
- Initiating Organization: European Commission
- Initiator Type: Government
- Disease focus:
Tuberculosis - Location: International
Abstract
The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), which delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment.
Mission
The MM4TB research consortium has been assembled to discover anti-infective agents that will combat TB. Evolved from the FP6 project, New Medicines for TB (NM4TB) - which successfully delivered a candidate drug for clinical development two years ahead of schedule - the MM4TB team will apply an integrated approach that includes tripartite screening strategies and medicinal chemistry, functional genomics and structural biology. This combination of approaches is a broad strategy to discover new compounds, perform pharmacological validation, identify targets, and analyze a variety of mechanisms of action during Mycobacterium tuberculosis (M. tb) infection.
Consortium History
The consortium’s original project was titled New Medicines for TB (NM4TB), which successfully discovered the benzothiazinone (BTZ) series, now in late stage preclinical development. Now, MM4TB seeks to discover more anti-infective agents that will combat TB.
Structure & Governance
The consortium is overseen by the European Commission’s 7th Framework Programme
Financing
Funding for MM4TB is made available by the European Commission’s 7th Framework Programme
Impact/Accomplishment
A resource list of MM4TB publications can be found on their website under the “Publications” tab.
Links/Social Media Feed
Homepage |
http://www.mm4tb.org/ |
Points of Contact
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
BATIMENT CE 3316 STATION 1
1015 LAUSANNE
Switzerland
Activity type: Higher or Secondary Education Establishments
Administrative contact: Stewart Cole
Tel.: +41216931851
Fax: +41216931790
Sponsors & Partners
The École Polytechnique Fédérale de Lausanne (EPFL) |
AstraZeneca |
Sanofi-aventis |
Alere |
Vichem |
Cellworks |
CDD |
Tydock |
Uppsala University |
Pavia University |
University of Cambridge |
Queen Mary’s University |
University of London |
Padova University |
Comenius University |
Piemonte Oreintale University |
Basque Country University |
University of Zaragoza |
ETH Zurich University |
Cape Town Unversity |
Institute Pasteur de Paris |
Institute Pasteur de Lille |
Bach Institute of Biochemistry |
John Innes Center |
Indian Academy of Sciences |