neuroGLIA Consortium
Research Areas
At a Glance
- Status: Completed Consortium
- Year Launched: 2008
- Initiating Organization: European Commission’s 7th Framework Programme
- Initiator Type: Government
- Disease focus:
Epilepsy - Location: Europe
Abstract
NeuroGLIA represents a concerted effort of European research groups dedicated to increase our knowledge on glial function and to unravel the role of neuron-glia interaction in the healthy and diseased brain. In particular, the consortium investigates glial cells in initiation and progression of epilepsy.
Mission
The following specific objectives were pursued with this project:
- integrated characterization of astroglial cell subtypes with respect to neuron-gliainteractions;
- identification of molecular and signaling pathways from neuron-to-astroglia and astrogliato-neuron in situ and in vivo;
- temporal and spatial dynamics of astroglia-neuron interaction in the normal and epileptic brain in situ and in vivo;
- identification of the role of astroglia in neurovascular coupling in the normal and epileptic brain;
- characterization of inflammation-related deregulation of astroglia-neuron signaling in epilepsy;
- neuron-astroglia signaling in living human brain tissue.
Structure & Governance
The consortium is a project of the European Commission’s 7th Framework Programme
Financing
Funded by the European Commission’s 7th Framework Programme
Impact/Accomplishment
The projects major scientific and technological results can be summarized as follows:
- Performed a thorough and integrated characterization of astroglial cell subtypes with respect to neuron-glia interactions.
- Identified many molecular and signaling pathways from neuron-to-astroglia and astroglia-to-neuron in situ and in vivo.
- Investigated the temporal and spatial dynamics of astroglia-neuron interaction in the normal and epileptic brain in situ and in vivo.
- Have investigated the role of astroglia in neurovascular coupling in the normal and epileptic brain.
- Characterized inflammation-related deregulation of astroglia-neuron signaling in epilepsy.
- Investigated neuron-astroglia signaling in living human brain tissue.
Links/Social Media Feed
Homepage |
http://www.neuroglia.eu/members.php |
Points of Contact
Christian Steinhäuser
Institute of Cellular Neurosciences
University of Bonn, Medical School
Sigmund-Freud-Str. 25
D-53105 Bonn
Germany
Phone +49-228-287 1 4669
Fax +49-228-287 1 9121
Sponsors & Partners
Consejo Superior De Investigaciones Cientificas |
Cardiff University |
Consiglio Nazionale Delle Ricerche |
Max Planck Gesellschaft Zur Foerderung Der Wissenschaften E.V. |
Academisch Medisch Centrum |
European Research and Project Office GMBH |
Universitaet Des Saarlandes |