The Neurofibromatosis Therapeutic Consortium (NFTC)
At a Glance
- Status: Completed Consortium
- Year Launched: 2013
- Initiating Organization: The Children’s Tumor Foundation
- Initiator Type: Nonprofit foundation
- Disease focus:
- Location: North America
The Neurofibromatosis Therapeutic Consortium (NFTC) brought together four labs to find novel targets for clinical trials. These two consortia cooperated to perform and complete 111 preclinical trials across different models. These studies identified 12 drug targets with promising efficacy, and 16 clinical trials have occurred based on the veracious preclinical data gathered by NFPC and NFTC investigators.
The NFTC was focused on NF1 and included sites investigating animal models of plexiform neurofibromas, MPNSTs, and NF1- associated leukemia. To continue the NFPC’s work on NF2, the Foundation launched the Synodos initiative.
The NFTC (NF Therapeutic Consortium) was launched at the conclusion of the NFPC as a three year $4 million program to follow up the work of the NFPC. The NFTC was focused on NF1 and included sites investigating animal models of plexiform neurofibromas, MPNSTs, and NF1- associated leukemia. To continue the NFPC’s work on NF2, the foundation launched the Synodos initiative.
Structure & Governance
The NFTC was created and run by the Children’s Tumor Foundation and then continued as the Synodos initiative.
This three-year, $4 million collaboration was co-funded with NTAP (Neurofibromatosis Therapeutic Acceleration Program) and was an extension of the Neurofibromatosis Preclinical Consortium (NFPC), a five-year, $7 million program that concluded in 2013.
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Studies identified 12 drug targets with promising efficacy, and 16 clinical trials have occurred based on the veracious preclinical data gathered by NFPC and NFTC investigators.
Points of Contact
120 Wall Street, 16th Floor
New York, NY 10005-3904
Sponsors & Partners
Benjamin Braun, University of California
Karen Cichowski, Harvard Medical School/Brigham and Women’s Hospital
D. Wade Clapp, Indiana University School of Medicine
Nancy Ratner, Cincinnati Children’s Hospital Medical Center