New York Structural Genomics Research Consortium (NYSGRC)


At a Glance
  • Status: Completed Consortium
  • Year Launched: 2010
  • Initiating Organization: National Institutes of Health
  • Initiator Type: Government
  • No disease focus
  • Location: North America

Abstract

The NYSGRC, lead by Steven Almo and composed of additional investigators from Einstein, Brookhaven National Laboratory, University of Virginia, and UCSF, is one of four high-throughput production centers for the NIH NIGMS Protein Structure Initiative (PSI). During the five year phase of the program (PSI:Biology, 2010 to 2015), the general scope of grant activities includes high-throughput protein expression, crystallization, and structure determination with an emphasis on addressing the challenges associated with eukaryotic proteins and complexes. This infrastructure will enable the research activities of a base of collaborating biologists from the NIH PSI Network and the broader biological research community. These researchers nominate protein targets of significant biological interest and the production centers generate reagents (including expression clones and purified proteins) and X-ray crystal structures to facilitate investigations into the biological activity of the targets.

Mission

The NYSGRC will complement high-throughput structure determination capabilities with biochemical and computational approaches to establish an integrated platform with the capabilities and flexibility to meet the wide ranging and dynamic challenges inherent in integrating structure and biology within the collaborative framework of the PSI:Biology Network. NYSGRC efforts address three structure determination target classes: program, bio-medical theme, and community outreach.  

Structure & Governance

The consortium was created by the NIH and individual members are responsible for consortium governance.

Financing

Funding is provided by a National Institute of General Medicine Sciences grant, which is part of the NIH.

Data Sharing

The NYSGRC and its partner centers have also established numerous additional collaborations with a wide range of scientists including enzymologists, bacteriologists, immunologists, bioinformaticians, and cryo-EM spectroscopists in which materials and information generated for target proteins will be actively shared to leverage the work product of the PSI.

Impact/Accomplishment

Over the past ten years, the NYSGRC has evolved a series of core activities that support all aspects of the Protein Structure Initiative (PSI):

- Data Management/LIMS
Tool that efficiently tracks all activities within the NYSGRC, including all required reporting activities and coordination with other elements of the PSI network

- Bioinformatics
For target identification, ortholog expansion, construct design, homology modeling, structure leverage and annotation

- Protein Production
For high-throughput cloning, expression, purification and quality control

- Structure Determination
For high-throughput crystallization, data collection and structure determination

- Technology Development
For new approaches to augment the existing high-throughput pipeline (e.g., novel protein expression technologies) and the development and utilization of cutting-edge biochemical and computational technologies that complement and leverage structure data.

Points of Contact

Department of Biochemistry
Department of Physiology & Biophysics
Albert Einstein College of Medicine
Bronx, NY 10461
almo at aecom.yu.edu

Sponsors & Partners

Albert Einstein College of Medicine

Brookhaven National Laboratory

University of California

University of Virginia

University of Washington


Last Updated: 06/26/2017

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