At a Glance
- Status: Completed Consortium
- Year Launched: 2008
- Initiating Organization: European Commission’s 7th Framework Programme (FP7)
- Initiator Type: Government
- No disease focus
- Location: Europe
SYBILLA develops new analytical and mathematical tools to generate and integrate high-density quantitative data describing T-cell activation. Proteomics, transcriptomics, imaging, and biochemical techniques will be applied to obtain holistic maps of the T-cell signaling network and to achieve a quantitative and dynamic understanding of signaling networks and their regulation in response to different signal inputs. Building upon already existing schemes of the network connectivity, constant iteration between experiment and mathematical modelling will be used to develop robust and predictive models that describe the functioning of the T-cell signaling network. SYBILLA will allow the identification of new drug targets and the discovery of new biomarkers to refine prognosis of autoimmune diseases.
The goal of SYBILLA is to understand the intracellular network of T cells that determines T cell fate. Through a multidisciplinary effort SYBILLA aims to understand at systems level, how T-cells discriminate foreign- from self-peptides by activating quantitatively distinct signaling pathways. Data obtained in mouse models are extended to human T cells and to a mouse model of multiple sclerosis.
Structure & Governance
Lead by Dr. Wolfgang Schamel, University of Freiburg, Freiburg, Germany
European Union-funded large integrated project in framework program 7 (FP7).
For a list of SYBILLA scientific publications, click here
Points of Contact
PD Dr. Wolfgang Schamel
Dept. of Molecular Immunology
Sponsors & Partners
The Signal Transduction Society
The Immunological Genome Project
The Immune Response Consortium