At a Glance
  • Status: Completed Consortium
  • Year Launched: 2008
  • Initiating Organization: European Commission’s 7th Framework Programme (FP7)
  • Initiator Type: Government
  • No disease focus
  • Location: Europe

Abstract

SYBILLA develops new analytical and mathematical tools to generate and integrate high-density quantitative data describing T-cell activation. Proteomics, transcriptomics, imaging, and biochemical techniques will be applied to obtain holistic maps of the T-cell signaling network and to achieve a quantitative and dynamic understanding of signaling networks and their regulation in response to different signal inputs. Building upon already existing schemes of the network connectivity, constant iteration between experiment and mathematical modelling will be used to develop robust and predictive models that describe the functioning of the T-cell signaling network. SYBILLA will allow the identification of new drug targets and the discovery of new biomarkers to refine prognosis of autoimmune diseases.

Mission

The goal of SYBILLA is to understand the intracellular network of T cells that determines T cell fate. Through a multidisciplinary effort SYBILLA aims to understand at systems level, how T-cells discriminate foreign- from self-peptides by activating quantitatively distinct signaling pathways. Data obtained in mouse models are extended to human T cells and to a mouse model of multiple sclerosis.   

Structure & Governance

Lead by Dr. Wolfgang Schamel, University of Freiburg, Freiburg, Germany

Financing

European Union-funded large integrated project in framework program 7 (FP7).

Impact/Accomplishment

For a list of SYBILLA scientific publications, click here

Points of Contact

PD Dr. Wolfgang Schamel
Dept. of Molecular Immunology
University Freiburg
Schänzlestr. 18
79104 Freiburg
Germany

Tel: +49-(0)761-203-67511
Fax: +49-(0)761-5108-423
wolfgang.schamel@biologie.uni-freiburg.de

Sponsors & Partners

The Signal Transduction Society

The Immunological Genome Project

The Immune Response Consortium


Last Updated: 06/21/2017

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