Synodos for NF2
Research Areas
At a Glance
- Status: Active Consortium
- Year Launched: 2016
- Initiating Organization: Children’s Tumor Foundation
- Initiator Type: Nonprofit foundation
- Rare disease
- Disease focus:
Neurofibromatosis - Location: North America
Abstract
Neurofibromatosis Type 2 (NF2) is characterized by tumors that develop throughout the central and peripheral nervous system. Though NF2 tumors are benign, these patients experience significant morbidity and mortality because of the location of the tumors, their compressive effects, and the effects of current treatments. Synodos for NF2 is a $3 million, multi-year initiative that has assembled a team of researchers from twelve world-class labs and medical centers. This comprehensive, collaborative model brought together experts in basic, translational, and clinical research, who have joined forces to share information, free of bureaucratic obstacles and institutional competition.
Mission
The goal of Synodos for NF2 is to discover novel therapeutic agents for clinical treatment, that either successfully shrink NF2 tumor types, or halt tumor growth without long-term toxicity, or with a manageable long-term toxicity profile. Synodos for NF2 aims to deliver multiple new and advanced cell and animal models to accelerate drug screening, new target pathways, and an increased understanding of response and resistance to treatment. Eventually this work will result in new clinical trials for NF2, and effective combination therapies.
Consortium History
Synodos was born from the Children’s Tumor Foundation’s dissatisfaction with the scientific research process. It models an approach that promotes data sharing and collaboration rather than data hording and competition so as to more efficiently and quickly accelerate the cancer research process.
Structure & Governance
Developed by the Children’s Tumor Foundation
Financing
Funded by the Children’s Tumor Foundation
Patient Engagement
The consortium recruits patients for testing of clinical trials
Links/Social Media Feed
Homepage |
http://www.ctf.org/research/synodos#nf2 |
Points of Contact
Salvatore La Rosa, PhD
slarosa@ctf.org
120 Wall Street, 16th Floor
New York, NY 10005
Sponsors & Partners
Children’s Tumor Foundation |
Washington University |
German Cancer Research Center |
University of California SF |
Children’s Hospital of Philadelphia |
University of Minnesota |
Cincinnati Children’s Hospital |
National Cancer Institute |
Recombinetics, Inc. |
University of Iowa |
Sanford School of Medicine |
Exempler Genetics |
University of Florence |
University of Toronto |